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Anti-GULP1 Antibody (CAB3432)

SKU:
CAB3432
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Death
  • Cell Death Antibodies 2 Anti-GULP1 Antibody CAB3432
  • Cell Death Antibodies 2 Anti-GULP1 Antibody CAB3432
  • Cell Death Antibodies 2 Anti-GULP1 Antibody CAB3432
  • Cell Death Antibodies 2 Anti-GULP1 Antibody CAB3432
€139 - €419
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Description

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Antibody Name:Anti-GULP1 Antibody
Antibody SKU:CAB3432
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human GULP1 (NP_057399.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, 293T, Mouse lung, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human GULP1 (NP_057399.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MNRA FSRK KDKT WMHT PEAL SKHF IPYN AKFL GSTE VEQP KGTE VVRD AVRK LKFA RHIK KSEG QKIP KVEL QISI YGVK ILEP KTKE VQHN CQLH RISF CADD KTDK RIFT FICK DSES NKHL CYVF DS
Gene ID:51454
Uniprot:Q9UBP9
Cellular Location:Cytoplasm
Calculated MW:19kDa/22kDa/33kDa/34kDa
Observed MW:34kDa
Synonyms:GULP1, CED-6, CED6, GULP
Background:The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene.
UniProt Protein Function:GULP1: May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6. Belongs to the ced-6 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 2q32.3-q33

Cellular Component: cytoplasm

Molecular Function:signal transducer activity

Biological Process: apoptosis; phagocytosis, engulfment; lipid transport; signal transduction

NCBI Summary:The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene. [provided by RefSeq, Nov 2011]
UniProt Code:Q9UBP9
NCBI GenInfo Identifier:74720076
NCBI Gene ID:51454
NCBI Accession:Q9UBP9.1
UniProt Secondary Accession:Q9UBP9,Q53PC1, Q53RF3, Q9BVL3, B2RB51, B4DQ40, B8ZZ72 D3DPH1, E9PB86,
UniProt Related Accession:Q9UBP9
Molecular Weight:304
NCBI Full Name:PTB domain-containing engulfment adapter protein 1
NCBI Synonym Full Names:GULP, engulfment adaptor PTB domain containing 1
NCBI Official Symbol:GULP1  
NCBI Official Synonym Symbols:CED6; GULP; CED-6  
NCBI Protein Information:PTB domain-containing engulfment adapter protein 1; cell death protein 6 homolog; PTB domain adapter protein CED-6; PTB domain adaptor protein CED-6
UniProt Protein Name:PTB domain-containing engulfment adapter protein 1
UniProt Synonym Protein Names:Cell death protein 6 homolog; PTB domain adapter protein CED-6; Protein GULP
Protein Family:PTB domain-containing engulfment adapter protein
UniProt Gene Name:GULP1  
UniProt Entry Name:GULP1_HUMAN
Anti-GULP1 Antibody (CAB3432)Western blot analysis of extracts of various cell lines, using GULP1 antibody (CAB3432) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
Anti-GULP1 Antibody (CAB3432)Immunohistochemistry of paraffin-embedded Mouse spinal cord using GULP1 Rabbit pAb (CAB3432) at dilution of 1:100 (40x lens).
Anti-GULP1 Antibody (CAB3432)Immunohistochemistry of paraffin-embedded Rat ovary using GULP1 Rabbit pAb (CAB3432) at dilution of 1:100 (40x lens).
Anti-GULP1 Antibody (CAB3432)Immunohistochemistry of paraffin-embedded Human colon carcinoma using GULP1 Rabbit pAb (CAB3432) at dilution of 1:100 (40x lens).

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