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Anti-HAUSP / USP7 Antibody (CAB3448)

SKU:
CAB3448
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

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Antibody Name:Anti-HAUSP / USP7 Antibody
Antibody SKU:CAB3448
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human HAUSP / USP7
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, MCF7, PC-3, Mouse testis, Mouse brain, Rat testis, Rat brain
Immunogen:A synthesized peptide derived from human HAUSP / USP7
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7874
Uniprot:Q93009
Cellular Location:
Calculated MW:128kDa
Observed MW:140KDa
Synonyms:HAUSP, TEF1
Background:The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder. [provided by RefSeq, Mar 2016]
UniProt Protein Function:USP7: an enzyme that removes ubiquitin from its protein substrates. Binds to the herpes virus protein VMW110 that may therefore modulate its substrate specificity or activity to stabilize viral proteins. Regulates MDM2 and has a dynamic role in the p53-MDM2 pathway. Is reported to deubiquitinate and stabilize p53.
UniProt Protein Details:

Protein type:Ubiquitin-specific protease; Protease; EC 3.4.19.12; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: nuclear body; PML body; cytosol; nucleus

Molecular Function:protein C-terminus binding; protein binding; p53 binding; cysteine-type endopeptidase activity; ubiquitin protein ligase binding; ubiquitin-specific protease activity; transcription factor binding

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; maintenance of DNA methylation; viral reproduction; regulation of transcription factor activity; inhibition of NF-kappaB transcription factor; transcription-coupled nucleotide-excision repair; multicellular organismal development; histone deubiquitination

UniProt Code:Q93009
NCBI GenInfo Identifier:212276477
NCBI Gene ID:7874
NCBI Accession:Q93009.2
UniProt Secondary Accession:Q93009,A6NMY8, B7Z815, H0Y3G8,
UniProt Related Accession:Q93009
Molecular Weight:1102
NCBI Full Name:Ubiquitin carboxyl-terminal hydrolase 7
NCBI Synonym Full Names:ubiquitin specific peptidase 7 (herpes virus-associated)
NCBI Official Symbol:USP7  
NCBI Official Synonym Symbols:TEF1; HAUSP  
NCBI Protein Information:ubiquitin carboxyl-terminal hydrolase 7; ubiquitin thioesterase 7; deubiquitinating enzyme 7; ubiquitin-specific-processing protease 7; herpesvirus-associated ubiquitin-specific protease; Herpes virus-associated ubiquitin-specific protease; ubiquitin spec
UniProt Protein Name:Ubiquitin carboxyl-terminal hydrolase 7
UniProt Synonym Protein Names:Deubiquitinating enzyme 7; Herpesvirus-associated ubiquitin-specific protease; Ubiquitin thioesterase 7; Ubiquitin-specific-processing protease 7
UniProt Gene Name:USP7  
UniProt Entry Name:UBP7_HUMAN
Anti-HAUSP / USP7 Antibody (CAB3448)Western blot - HAUSP / USP7 Rabbit mAb (CAB3448)

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