Anti-HBD Antibody (CAB9220)
- SKU:
- CAB9220
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
Anti-HBD Antibody (CAB9220)
The HBD Polyclonal Antibody (CAB9220) is a high-quality antibody designed for research involving the human HBD protein. HBD, also known as beta-defensin, is a key component of the immune system, playing a critical role in antimicrobial defense. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. The HBD Polyclonal Antibody binds specifically to the HBD protein, enabling accurate detection and analysis in various cell types.
This antibody is ideal for studies in immunology and infectious disease research, as understanding the function of HBD can provide insights into host-defense mechanisms against pathogens.Overall, the HBD Polyclonal Antibody is a valuable tool for researchers investigating immune responses, antimicrobial defense, and potential therapeutic strategies for infectious diseases. Its specificity and sensitivity make it a reliable choice for studies aiming to uncover the role of HBD in health and disease.
| Antibody Name: | Anti-HBD Antibody |
| Antibody SKU: | CAB9220 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human HBD (NP_000510.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse lung, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human HBD (NP_000510.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MVHL TPEE KTAV NALW GKVN VDAV GGEA LGRL LVVY PWTQ RFFE SFGD LSSP DAVM GNPK VKAH GKKV LGAF SDGL AHLD NLKG TFSQ LSEL HCDK LHVD PENF RLLG NVLV CVLA RNFG KEFT PQMQ AAYQ KVVA GVAN ALAH KYH |
| Gene ID: | 3045 |
| Uniprot: | P02042 |
| Cellular Location: | |
| Calculated MW: | 16kDa |
| Observed MW: | 13kDa |
| Synonyms: | HBD |
| Background: | The delta (HBD) and beta (HBB) genes are normally expressed in the adult: two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin. Two alpha chains plus two delta chains constitute HbA-2, which with HbF comprises the remaining 3% of adult hemoglobin. Five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon--Ggamma--Agamma--delta--beta-3'. Mutations in the delta-globin gene are associated with beta-thalassemia. |
| UniProt Protein Function: | HBD: Involved in oxygen transport from the lung to the various peripheral tissues. Belongs to the globin family. |
| UniProt Protein Details: | Protein type:Carrier Chromosomal Location of Human Ortholog: 11p15.5 Cellular Component: hemoglobin complex; cytosol Molecular Function:iron ion binding; heme binding; oxygen binding; oxygen transporter activity Biological Process: oxygen transport; blood coagulation |
| NCBI Summary: | The delta (HBD) and beta (HBB) genes are normally expressed in the adult: two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin. Two alpha chains plus two delta chains constitute HbA-2, which with HbF comprises the remaining 3% of adult hemoglobin. Five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon--Ggamma--Agamma--delta--beta-3'. Mutations in the delta-globin gene are associated with beta-thalassemia. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P02042 |
| NCBI GenInfo Identifier: | 4504351 |
| NCBI Gene ID: | 3045 |
| NCBI Accession: | NP_000510.1 |
| UniProt Secondary Accession: | P02042,Q3Y5H3, Q8WXT7, |
| UniProt Related Accession: | P02042 |
| Molecular Weight: | |
| NCBI Full Name: | hemoglobin subunit delta |
| NCBI Synonym Full Names: | hemoglobin, delta |
| NCBI Official Symbol: | HBDÂ Â |
| NCBI Protein Information: | hemoglobin subunit delta; delta globin; delta-globin chain; hemoglobin delta chain |
| UniProt Protein Name: | Hemoglobin subunit delta |
| UniProt Synonym Protein Names: | Delta-globin; Hemoglobin delta chain |
| Protein Family: | Hemoglobin |
| UniProt Gene Name: | HBDÂ Â |
| UniProt Entry Name: | HBD_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HBD antibody (CAB9220) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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