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Anti-HDAC11 Antibody (CAB6140)

SKU:
CAB6140
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
  • Epigenetics and Nuclear Signaling Antibodies 2 Anti-HDAC11 Antibody CAB6140
  • Epigenetics and Nuclear Signaling Antibodies 2 Anti-HDAC11 Antibody CAB6140
  • Epigenetics and Nuclear Signaling Antibodies 2 Anti-HDAC11 Antibody CAB6140
€139 - €419
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Description

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Antibody Name:Anti-HDAC11 Antibody
Antibody SKU:CAB6140
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 270-347 of human HDAC11 (NP_079103.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse small intestine, BT-474, MCF7, Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 270-347 of human HDAC11 (NP_079103.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GLSI SPAG IVKR DELV FRMV RGRR VPIL MVTS GGYQ KRTA RIIA DSIL NLFG LGLI GPES PSVS AQNS DTPL LPPA VP
Gene ID:79885
Uniprot:Q96DB2
Cellular Location:Nucleus
Calculated MW:33kDa/39kDa
Observed MW:39kDa
Synonyms:HDAC11, HD11
Background:This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:HDAC11: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Belongs to the histone deacetylase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.5.1.98; Deacetylase

Chromosomal Location of Human Ortholog: 3p25.1

Cellular Component: histone deacetylase complex; nucleus; plasma membrane

Molecular Function:histone deacetylase activity; transcription factor binding

Biological Process: chromatin modification; histone deacetylation

NCBI Summary:This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]
UniProt Code:Q96DB2
NCBI GenInfo Identifier:26394832
NCBI Gene ID:79885
NCBI Accession:Q96DB2.1
UniProt Secondary Accession:Q96DB2,Q9H6I7, Q9H6X3, Q9NTC9, B4DDK1,
UniProt Related Accession:Q96DB2
Molecular Weight:33,124 Da
NCBI Full Name:Histone deacetylase 11
NCBI Synonym Full Names:histone deacetylase 11
NCBI Official Symbol:HDAC11  
NCBI Official Synonym Symbols:HD11  
NCBI Protein Information:histone deacetylase 11
UniProt Protein Name:Histone deacetylase 11
Protein Family:Histone deacetylase
UniProt Gene Name:HDAC11  
UniProt Entry Name:HDA11_HUMAN
Anti-HDAC11 Antibody (CAB6140)Western blot analysis of extracts of mouse small intestine, using HDAC11 antibody (CAB6140) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
Anti-HDAC11 Antibody (CAB6140)Western blot analysis of extracts of various cell lines, using HDAC11 antibody (CAB6140) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
Anti-HDAC11 Antibody (CAB6140)Western blot analysis of extracts of various cell lines, using HDAC11 antibody (CAB6140) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s.

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