HDAC4 Rabbit Monoclonal Antibody

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SKU:
CAB13510
€129 - €349

Description

Technical Manual

HDAC4 Rabbit Monoclonal Antibody

Product Name:HDAC4 Rabbit Monoclonal Antibody
Product SKU:CAB13510
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]

Immunogen:A synthesized peptide derived from human HDAC4
Sequence:

Email for sequence

Gene ID:9759
Swiss Prot:P56524
Synonyms:AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A; HDACA
Calculated MW:140kDa
Observed MW:140KDa
Reactivity:Mouse, Rat
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting 
Positive Samples:Mouse lung, Mouse testis, Rat lung, Rat testis
Cellular Location:

Product Images

HDAC4 Rabbit Monoclonal Antibody

Western blot - HDAC4 Rabbit mAb (CAB13510)

Uniprot Information

UniProt Protein Function:HDAC4: a transcriptional regulator of the histone deacetylase family, subfamily 2. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
UniProt Protein Details:

Protein type:Hydrolase; EC 3.5.1.98; Deacetylase; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: nucleoplasm; transcriptional repressor complex; histone deacetylase complex; cytoplasm; actomyosin; neuromuscular junction; nucleus; Z disc; cytosol; A band

Molecular Function:potassium ion binding; transcription activator binding; zinc ion binding; histone deacetylase binding; protein deacetylase activity; protein kinase binding; transcription factor binding; protein binding; NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H3-K14 specific); sequence-specific DNA binding; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; transcription corepressor activity

Biological Process: cardiac muscle hypertrophy; response to drug; nervous system development; regulation of skeletal muscle fiber development; transcription, DNA-dependent; B cell activation; negative regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; histone deacetylation; response to denervation involved in regulation of muscle adaptation; negative regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic; osteoblast development; positive regulation of protein sumoylation; chromatin remodeling; negative regulation of cell proliferation; B cell differentiation; regulation of protein binding; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; negative regulation of osteoblast differentiation; negative regulation of transcription, DNA-dependent; negative regulation of glycolysis; inflammatory response; skeletal development

NCBI Summary:Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]
UniProt Code:P56524
NCBI GenInfo Identifier:259016348
NCBI Gene ID:9759
NCBI Accession:P56524.3
UniProt Secondary Accession:P56524,Q86YH7, Q9UND6, E9PGB9, F5GX36,
UniProt Related Accession:P56524
Molecular Weight:Calculated MW: 106kDa/119kDaObserved MW: 117kDa
NCBI Full Name:Histone deacetylase 4
NCBI Synonym Full Names:histone deacetylase 4
NCBI Official Symbol:HDAC4 
NCBI Official Synonym Symbols:HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A 
NCBI Protein Information:histone deacetylase 4; histone deacetylase A
UniProt Protein Name:Histone deacetylase 4
UniProt Gene Name:HDAC4 
UniProt Entry Name:HDAC4_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
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