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Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Hsp90 alpha/beta Monoclonal Antibody, Clone K41220A (STMA00019). Tissue: Cervical cancer cell line (HeLa). Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Mouse Anti-Hsp90 alpha/beta Monoclonal Antibody (STMA00019) at 1:100 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:200 for 2 hours at RT.
Key Features

Anti-HSP90 alpha/beta Antibody [Hyb-K41220A]

Datasheet
SKU STMA00019
Antibody Type Monoclonal
Applications WB
Applications IHC
Applications ICC/IF
Applications ELISA
Reactivity Human
Reactivity Mouse
Reactivity Rat
Reactivity Yeast
Reactivity Yeast (Saccharomyces cerevisiae)
Reactivity Fisson Yeast (Schizosaccharomyces pombe)
Host Species Mouse
Isotype IgG2a
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Description

HSP90 alpha/beta Antibody [Hyb-K41220A]

HSP90 alpha/beta Antibody [Hyb-K41220A] is a mouse monoclonal antibody directed against HSP90 alpha/beta, offered by Assay Genie for research applications. Reported applications include WB, IHC, ICC/IF and ELISA. Reported reactivity: Human, Mouse, Rat, Yeast, Yeast (Saccharomyces cerevisiae) and Fisson Yeast (Schizosaccharomyces pombe). Supplied as IgG2a, purified by Protein G.

HSP90α and HSP90β are the two major cytosolic isoforms of the highly conserved heat shock protein 90 (HSP90) family, essential for maintaining protein homeostasis in all eukaryotic cells. While they share 85% amino acid sequence identity, the isoforms differ in structure and function: HSP90α primarily forms homodimers and is stress-inducible, whereas HSP90β exists mainly as a monomer and is constitutively expressed. Both isoforms are abundantly expressed in the brain and play critical roles in the folding, maturation, and stabilization of a wide range of client proteins involved in neuronal signaling, synaptic plasticity, and cellular stress responses. These include kinases (e.g., c-Raf), transcription factors (e.g., p53), and hormone receptors—many of which are implicated in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s disease. HSP90α and HSP90β function as part of dynamic chaperone complexes, interacting with co-chaperones like Cdc37 and p23. ATP binding drives conformational changes that enable these complexes to stabilize client proteins and prevent their degradation. However, in disease contexts, this protective mechanism can inadvertently preserve toxic protein species, contributing to pathogenesis. By recognizing both HSP90α and HSP90β, this antibody provides a powerful tool for researchers exploring the dual roles of HSP90 in neuronal health and disease. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, Biotin and FITC. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.

Product Name:HSP90 alpha/beta Antibody [Hyb-K41220A]
Product SKU:STMA00019
Size:100 µg
Target:HSP90 alpha/beta
Host Species:Mouse
Antibody Type:Monoclonal
Clone ID:Hyb-K41220A
Research Areas:Cancer, Heat Shock, Cell Signaling, Protein Trafficking, Chaperone Proteins, Cancer, Tumor Biomarkers
Buffer:PBS pH7.2, 50% glycerol, 0.09% sodium azide
Storage & Shipping:Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:Liquid
Applications:WB, IHC, ICC/IF, ELISA
Antibody Isotype:IgG2a
Purification:Protein G Purified
Concentration:1 mg/ml
Reactivity:Human, Mouse, Rat, Yeast, Yeast (Saccharomyces cerevisiae), Fisson Yeast (Schizosaccharomyces pombe)
Recommended Dilution:WB (1:1000), IHC (1:100), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Specificity:Detects 90kDa. Will detect both alpha (inducible) and beta (constitutively-expressed) forms.
Guarantee:12 months from date of dispatch
Immunogen:Recombinant human HSP90alpha; Specificity mapped to amino acids 291-304
Immunogen Species:Human
Accession Number:NP_031381.2, NP_001017963.2
Gene ID:3326, 3320
Swiss-Prot:P08238, P07900
Cellular Localization:Cytoplasm | Melanosome
Alternative Names:HSP90AA1, HSP90AB1, HSP90-alpha, HSP90-beta, HSP90A, HSP90B, HSP89A, HSP86, HSP84, HSP90Alpha, HSPCA, HSPC1, HSPC2, HSPCB, HSPCAL3, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock 90 kDa protein 1 alpha isoform, Heat shock 84 kDa protein, D6S182, FLJ26984
References:1. Nemoto, T. et al. (1997) J.Biol Chem. 272: 26179-26187. 2. Minami Y, et al. (1991), J.Biol Chem. 266: 10099-10103. 3. Arlander SJH, et al. (2003) J Biol Chem 278: 52572-52577. 4. Pearl H, et al. (2001) Adv Protein Chem 59: 157-186. 5. Neckers L, et al. (2002) Trends Mol Med 8: S55-S61. 6. Pratt W, Toft D. (2003) Exp Biol Med 228: 111-133. 7. Pratt W, Toft D. (1997) Endocr Rev 18: 306–360. 8. Pratt WB. (1998) Proc Soc Exptl Biol Med 217: 420–434. 9. Whitesell L, et al. (1994) Proc Natl Acad Sci USA 91: 8324–8328. 10. Kishimoto J, et al. (2005). Cell Stress and Chaperones. 10 (4): 296-311.
Note:For research use only.
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