| Synonyms: | HSP90AA1, EL52, HEL-S-65p, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp103, Hsp89, Hsp90, LAP-2, LAP2 |
| Background: | The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11274138, PubMed:11276205, PubMed:15577939, PubMed:15937123, PubMed:27353360). |
| NCBI Summary: | The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
| UniProt Code: | P07900 |
| NCBI GenInfo Identifier: | 92090606 |
| NCBI Gene ID: | 3320 |
| NCBI Accession: | P07900.5 |
| UniProt Secondary Accession: | P07900,Q2PP14, Q5CAQ6, Q5CAQ7, Q9BVQ5, A8K500, B3KPJ9 |
| UniProt Related Accession: | P07900 |
| Molecular Weight: | 98,161 Da |
| NCBI Full Name: | Heat shock protein HSP 90-alpha |
| NCBI Synonym Full Names: | heat shock protein 90 alpha family class A member 1 |
| NCBI Official Symbol: | HSP90AA1Â Â |
| NCBI Official Synonym Symbols: | EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; LAP-2; HSP89A; HSP90A; HSP90N; Hsp103; HSPCAL1; HSPCAL4; HEL-S-65p  |
| NCBI Protein Information: | heat shock protein HSP 90-alpha |
| UniProt Protein Name: | Heat shock protein HSP 90-alpha |
| UniProt Synonym Protein Names: | Heat shock 86 kDa; HSP 86; HSP86; Lipopolysaccharide-associated protein 2; LAP-2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38 |
| Protein Family: | Heat shock protein |
| UniProt Gene Name: | HSP90AA1Â Â |
