Description
Human ABRAXAS1 Recombinant Protein (N-His)
Human ABRAXAS1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Ser174, with an N-terminal His tag. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. BRCA1-A complex subunit Abraxas 1 is a ~46 kDa protein. Involved in DNA damage response and double-strand break (DSB) repair. For research use only.
Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
| Product Name: | Human ABRAXAS1 Recombinant Protein (N-His) |
| SKU: | GXRP13101 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | ABRA1, ABRAXAS1, BRCA1-A complex subunit Abraxas 1, CCDC98, Coiled-coil domain-containing protein 98, FAM175A, Protein FAM175A |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Ser174 |
| UniProt: | Q6UWZ7 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
