Description
Human ADCY8 Recombinant Protein (N-His)
Human ADCY8 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Phe927-Ile1220, with an N-terminal His tag. Predicted molecular weight: 35.75 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Adenylate cyclase type 8 (ADCY8) is a ~140 kDa protein. Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. For research use only.
Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells.
| Product Name: | Human ADCY8 Recombinant Protein (N-His) |
| SKU: | GXRP06310 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Adenylyl cyclase 8, Adenylate cyclase type VIII, AC8, ADCY8, Adenylate cyclase type 8, Ca(2+)/calmodulin-activated adenylyl cyclase, ATP pyrophosphate-lyase 8 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Phe927-Ile1220 |
| Calculated MW: | 35.75 kDa |
| UniProt: | P40145 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
