Recombinant Human AGER Protein (His Tag) (RPES6049)
Advanced Glycosylation End Product-Specific Receptor (AGER) belongs to the immunoglobulin superfamily of cell surface molecules. It lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Besides AGEs, AGER is also able to bind other ligands which is thought to result in pro-inflammatory gene activation. It is known that AGER serve as a mediator of both acute and chronic vascular inflammation in certain conditions such as atherosclerosis and in particular as a complication of diabetes. Furthermore, it plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.
Product Name:
Recombinant Human AGER Protein (His Tag)
SKU:
RPES6049
Size:
100μg, 20μg, 500μg, 1mg
Species:
Human
Synonyms:
AGER, Advanced Glycosylation End Product-Specific Receptor, RAGE, Receptor for Advanced Glycosylation End Products
Tag:
C-His
Sequence:
Met1-Ala342
Expression Host:
HEK293 Cells
Accession:
Q15109
Endotoxin:
< 1.0 EU/mg of the protein as determined by the LAL method
Purity:
> 95% as determined by reducing SDS-PAGE.
Calculated MW:
37.5 kDa
Observed MW:
45-50 kDa
Bio-Activity:
Not validated for activity
Form:
Lyophilized powder
Source:
HEK293 Cells-derived Human AGER protein Met1-Ala342, with an C-terminal His
Formulation:
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Reconstitution:
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Storage:
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to - 80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
