Description
Human ARNT/HIF1-beta Recombinant Protein (N-His)
Human ARNT/HIF1-beta Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Leu159-Val464, with an N-terminal His tag. Predicted molecular weight: 36.77 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Aryl hydrocarbon receptor nuclear translocator is a ~86 kDa protein. Required for activity of the AHR. For research use only.
Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (Probable). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia.
| Product Name: | Human ARNT/HIF1-beta Recombinant Protein (N-His) |
| SKU: | GXRP10613 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | ARNT, ARNT protein, Aryl hydrocarbon receptor nuclear translocator, BHLHE2, Class E basic helix-loop-helix protein 2, Dioxin receptor, nuclear translocator, HIF-1-beta, HIF1-beta, Hypoxia-inducible factor 1-beta, bHLHe2 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Leu159-Val464 |
| Calculated MW: | 36.77 kDa |
| UniProt: | P27540 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
