Description
Human ATP8B1 Recombinant Protein (N-His)
Human ATP8B1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Arg412-Lys949, with an N-terminal His tag. Predicted molecular weight: 63.88 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Phospholipid-transporting ATPase IC is a ~143 kDa protein. Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids, in particular phosphatidylcholines (PC), from the outer to the inner leaflet of the plasma membrane. For research use only.
May participate in the establishment of the canalicular membrane integrity by ensuring asymmetric distribution of phospholipids in the canicular membrane. Thus may have a role in the regulation of bile acids transport into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both and protect hepatocytes from bile salts. Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity. Participates in correct apical membrane localization of CDC42, CFTR and SLC10A2.
| Product Name: | Human ATP8B1 Recombinant Protein (N-His) |
| SKU: | GXRP11211 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | ATP8B1, ATPIC, ATPase class I type 8B member 1, EC:7.6.2.1, FIC1, Familial intrahepatic cholestasis type 1, P4-ATPase flippase complex alpha subunit ATP8B1, PFIC, Phospholipid-transporting ATPase IC |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Arg412-Lys949 |
| Calculated MW: | 63.88 kDa |
| UniProt: | O43520 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
