Description
Human BCAR3 Recombinant Protein (N-His)
Human BCAR3 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Glu533-Leu825, with an N-terminal His tag. Predicted molecular weight: 35.54 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Breast cancer anti-estrogen resistance protein 3 (BCAR3) is a ~92 kDa protein. Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers. For research use only.
Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis. Promotes insulin-mediated membrane ruffling. In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1. Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity.
| Product Name: | Human BCAR3 Recombinant Protein (N-His) |
| SKU: | GXRP05644 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | SH2 domain-containing protein 3B, Novel SH2-containing protein 2, SH2D3B, NSP2, Breast cancer anti-estrogen resistance protein 3, BCAR3 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Glu533-Leu825 |
| Calculated MW: | 35.54 kDa |
| UniProt: | O75815 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
