Description
Human BIRC5 Recombinant Protein (N-His)
Human BIRC5 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Asp142, with an N-terminal His tag. Predicted molecular weight: 18.55 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Baculoviral IAP repeat-containing protein 5 (BIRC5) is a ~16 kDa protein. Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. For research use only.
Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules.
| Product Name: | Human BIRC5 Recombinant Protein (N-His) |
| SKU: | GXRP00123 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | BIRC5, IAP4, Apoptosis inhibitor survivin, Apoptosis inhibitor 4, API4, Baculoviral IAP repeat-containing protein 5 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Asp142 |
| Calculated MW: | 18.55 kDa |
| UniProt: | O15392 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
