Description
Human BIRC7 Recombinant Protein (N-GST & C-His)
Human BIRC7 Recombinant Protein (N-GST & C-His) is a recombinant protein expressed in E. coli, spanning Ser86-Ser176, with an N-terminal GST tag and a C-terminal His tag. Predicted molecular weight: 38.67 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Baculoviral IAP repeat-containing protein 7 is a ~32 kDa protein. Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. For research use only.
Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine.
| Product Name: | Human BIRC7 Recombinant Protein (N-GST & C-His) |
| SKU: | GXRP11977 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | BIRC7, Baculoviral IAP repeat-containing protein 7, Baculoviral IAP repeat-containing protein 7 30kDa subunit, EC:2.3.2.27, KIAP, Kidney inhibitor of apoptosis protein, LIVIN, Livin, ML-IAP, MLIAP, Melanoma inhibitor of apoptosis protein, RING finger protein 50, RING-type E3 ubiquitin transferase BIRC7, RNF50, Truncated livin, p30-Livin, tLivin |
| Tag: | N-GST & C-His |
| Expression Host: | E. coli |
| Protein Length: | Ser86-Ser176 |
| Calculated MW: | 38.67 kDa |
| UniProt: | Q96CA5 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
