Description
Human CD158d/KIR2DL4 Recombinant Protein (C-His)
Human CD158d/KIR2DL4 Recombinant Protein (C-His) is a recombinant protein expressed in mammalian cells, spanning Met1-His242, with a C-terminal His tag. Predicted molecular weight: 27.52 kDa. Purity: >95% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Killer cell immunoglobulin-like receptor 2DL4 (CD158d/KIR2DL4) is a ~41 kDa protein. Receptor for non-classical major histocompatibility class Ib HLA-G molecules. For research use only.
Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy. May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells. Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent pro-inflammatory response.
| Product Name: | Human CD158d/KIR2DL4 Recombinant Protein (C-His) |
| SKU: | GXRP03884 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | KIR2DL4, KIR-103AS, KIR103AS, CD158d, CD158 antigen-like family member D, CD158D, MHC class I NK cell receptor KIR103AS, Killer cell immunoglobulin-like receptor 2DL4, G9P, Killer cell inhibitory receptor 103AS |
| Tag: | C-His |
| Expression Host: | Mammalian cells |
| Protein Length: | Met1-His242 |
| Calculated MW: | 27.52 kDa |
| UniProt: | Q99706 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >95% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
