KIR2DL4, also known as CD158d, is a member of the killer cell Ig-like receptor (KIR) family. KIRs are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous. NK cells and certain T cells contain the gene KIR2DL4. The KIR2DL4 protein activates the phagocytosis of NK cells, even though it contains an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytosolic tail. The ITIM was not required for KIR2DL4-induced lysis. KIR2DL4's activation signal was diminished by the blockade of another ITIM-containing receptor. KIR2DL4 activation-deficient molecules inhibited the CD16 signal, which was confirmed by blocking the signaling pathway. Human KIR2DL4/CD158D Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human KIR2DL4/CD158D Recombinant Protein (RPES1496)
Product Code:
RPES1496
Size:
100 µg
Species:
Human
Expressed Host:
CHO Stable Cells
Synonyms:
Killer Cell Immunoglobulin-Like Receptor 2DL4, CD158 Antigen-Like Family Member D, G9P, Killer Cell Inhibitory Receptor 103AS, KIR-103AS, MHC Class I NK Cell Receptor KIR103AS, CD158d, KIR2DL4, CD158D, KIR103AS
Accession:
ADY38409.1
Sequence:
Met 1-His242
Fusion tag:
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human KIR2DL4 (ADY38409.1)(Met1-His242) was expressed with six amino acids (LEVLFQ) at the C-terminus was expressed and purified.
Purity:
> 85 % as determined by reducing SDS-PAGE.
Mol Mass:
25.1 kDa
AP Mol Mass:
33-37 kDa
Formulation:
Lyophilized from sterile PBS, pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
