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Human CD226/DNAM-1 Antibody (COMPASS01) - SDS-PAGE
Key Features

Human CD226/DNAM-1 Antibody (COMPASS01) (GXBS00883)

Datasheet MSDS
SKU GXBS00883
Product Type Research Grade Biosimilar
Antibody Type Monoclonal
Host Species Human
Reactivity Human
Applications ELISA, FACS, Functional assay, Research in vivo
Clone ID COMPASS01
Isotype IgG2
$677 - $2,208

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Description

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Human CD226/DNAM-1 Antibody (COMPASS01)

Human CD226/DNAM-1 Antibody (COMPASS01) is a research-grade biosimilar monoclonal antibody targeting CD226. It is a human IgG2 antibody. Reactivity: Human. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, flow cytometry, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.

CD226 antigen (DNAM-1) is a ~38 kDa protein. Cell surface receptor that plays an important role in the immune system, particularly in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-cells and NK cells. Functions as a costimulatory receptor upon recognition of target cells, such as virus-infected or tumor cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112 on target cells, promotes the cytotoxic activity of NK cells and CTLs, enhancing their ability to kill these cells. Mechanistically, phosphorylation by Src kinases such as LYN of FYN, enables binding to adapter GRB2, leading to activation of VAV1, PI3K and PLCG1. Promotes also activation of kinases ERK and AKT, as well as calcium fluxes.

Product Name:Human CD226/DNAM-1 Antibody (COMPASS01)
SKU:GXBS00883
Size:100 µg, 1 mg
Antibody Type:Monoclonal Antibody
Clone:COMPASS01
Target:DNAX accessory molecule 1
Isotype:IgG2
Host Species:Human
Reactivity:Human
Applications:ELISA, FACS, Functional assay, Research in vivo
Expression Host:Mammalian cells
Synonyms:DNAX accessory molecule 1, DNAM-1, DNAM1, CD226 antigen, CD226
Purity:>95% purity as determined by SDS-PAGE.
Endotoxin Level:< 10 EU/mg
Formulation:0.01M PBS pH 7.4
State of Matter:Liquid
Regulatory Status:For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:Protein A/G purified from cell culture supernatant.
Storage and Handling:Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
UniProt:Q15762
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