Human CD24 (ATG 031) Antibody is a research-grade biosimilar monoclonal antibody. It is a human IgG antibody. Reactivity: Human. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, flow cytometry, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.
Signal transducer CD24 is a ~8 kDa protein. May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90.
Product Name:
Human CD24 (ATG 031) Antibody
SKU:
GXBS01037
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Clone:
ATG 031
Target:
Signal transducer CD24
Isotype:
IgG
Host Species:
Human
Reactivity:
Human
Applications:
ELISA, FACS, Functional assay, Research in vivo
Expression Host:
Mammalian cells
Synonyms:
ATG-031, ATG031, ATG031
Biological Activity:
ATG-031 potently binds to CD24-postive tumor cells, while showing no binding with parental HEK293 cells or hRBC [1]. ATG-031 blocks the interaction between CD24 and Siglec-10 and induces potent macrophage-dependent tumor cell phagocytosis [1]. ATG-031 induces a potent antibody-dependent cellular cytotoxicity against HT-29 tumor cells with an EC 50 of 0.27 nM [3]. ATG-031 (1-3 mg/kg, i.v., biweekly) significantly inhibits tumor growth and induces tumor regression in MC38-hCD24 mouse model [1]. ATG-031 exhibits potent antitumor activity in vivo as a single agent in syngeneic models such as MC38, CT26, and 4T1 [3]. ATG-031 demonstrates in vivo synergism with chemotherapies and checkpoint inhibitors [3]. ATG-031 (3 mg/kg, i.v., 2 doses) significantly increases T cell-associated immune response at the cellular and single-cell transcriptome levels in C57BL/6 mice bearing MC38-hCD24 tumors [3].
Purity:
>95% purity as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4
State of Matter:
Liquid
Regulatory Status:
For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
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