Description
Human CD45/PTPRC Recombinant Protein (C-His)
Human CD45/PTPRC Recombinant Protein (C-His) is a recombinant protein expressed in mammalian cells, spanning Gln26-Lys529, with a C-terminal His tag. Predicted molecular weight: 58.81 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Receptor-type tyrosine-protein phosphatase C (CD45/PTPRC) is a ~147 kDa protein. Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. For research use only.
Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity.
| Product Name: | Human CD45/PTPRC Recombinant Protein (C-His) |
| SKU: | GXRP05405 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Receptor-type tyrosine-protein phosphatase C, 3.1.3.48, Leukocyte common antigen, L-CA, T200, CD45, PTPRC, CD45 |
| Tag: | C-His |
| Expression Host: | Mammalian cells |
| Protein Length: | Gln26-Lys529 |
| Calculated MW: | 58.81 kDa |
| UniProt: | P08575 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
