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Biotin Anti-Human CD47 Antibody [CC2C6D4] (AGEL0250)

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SKU AGEL0250
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Human
Host Species Mouse
Isotype IgG1
Clone CC2C6D4
Conjugation Biotin
Applications FC
€75 - €188
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Description

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Biotin Anti-Human CD47 Antibody [CC2C6D4]

The Human CD47 Monoclonal Antibody (Biotin-Conjugated) is a cutting-edge tool for research in the field of immunology and cancer biology. This antibody, designated CC2C6D4 (AGEL0250), is meticulously designed for precise binding to CD47, a cell surface protein with multifaceted roles in immune regulation and cancer progression.Developed and validated for use with human samples, this antibody offers exceptional specificity and sensitivity in various applications, including immunohistochemistry and flow cytometry. By targeting CD47, a crucial player in immune evasion and tumor immune escape mechanisms, this antibody provides researchers with a powerful tool to investigate the intricate interactions between cancer cells and the immune system.

The CD47 monoclonal antibody holds immense potential for advancing our understanding of cancer biology and immunotherapy. With its ability to facilitate the detection and analysis of CD47 expression in diverse cell types, this antibody enables in-depth investigations into the mechanisms underlying cancer progression and immune evasion strategies. Unlock new insights into the complex interplay between the immune system and cancer cells with the Human CD47 Monoclonal Antibody (Biotin-Conjugated) CC2C6D4 (AGEL0250).

Product Title:Biotin Anti-Human CD47 Antibody [CC2C6D4]
SKU:AGEL0250
Size:25µg, 100µg
Clone No:CC2C6D4
Synonyms:Leukocyte surface antigen CD47;Cd47;Integrin-associated protein;IAP;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:Biotin Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:Biotin
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:Q08722
Gene ID:961
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD47 also known as Rh-associated protein, gp42, integrin-associated protein (IAP), and neurophilin, is a 42-52 kD member of the immunoglobulin superfamily containing a five-pass transmembrane attachment. Two splice variants have been described in the cytoplasmic tail, the shorter form is expressed in bone-marrow-derived cells, endothelial cells, and fibroblasts while the longer form is expressed by neural tissues. CD47 expression is widely distributed in hematopoietic cells including thymocytes, T cells, B cells, monocytes, platelets, and erythrocytes as well as epithelial cells, endothelial cells, fibroblasts, and neural tissues. CD47 functions as an adhesion molecule and thrombospondin receptor and is non-covalently associated with β3 integrins CD51/CD61, CD41/CD61. Thrombospondin is a ligand for CD47; in the absence of CD47 mice show defects in host defense and β3 integrin-dependent ligand binding, migration, and cellular activation. CD47 is also part of the Rh complex on erythrocytes.

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