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FITC Anti-Human CD47 Antibody [CC2C6D4] (AGEL0251)

Datasheet MSDS
SKU AGEL0251
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Human
Host Species Mouse
Isotype IgG1
Clone CC2C6D4
Conjugation FITC
Applications FC
€94 - €357

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Description

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FITC Anti-Human CD47 Antibody [CC2C6D4]

The Human CD47 Monoclonal Antibody FITC Conjugated (CC2C6D4) is a cutting-edge product designed for research applications involving CD47, a key protein involved in immune evasion and cancer progression. This monoclonal antibody, validated for use in flow cytometry and immunofluorescence, offers high specificity and sensitivity in detecting CD47 expression in human samples.CD47, also known as the "don't eat me" signal, is a crucial molecule that helps cancer cells evade immune surveillance by interacting with the SIRP-alpha receptor on macrophages. Understanding the dynamics of CD47 expression and its role in immune evasion mechanisms is vital for developing targeted immunotherapies and anti-cancer strategies.

By utilizing the Human CD47 Monoclonal Antibody FITC Conjugated (CC2C6D4), researchers can delve deeper into the biological functions of CD47 in various contexts, including cancer research, immunotherapy development, and autoimmune disease investigations. This antibody provides a powerful tool for studying the complex interplay between CD47 and the immune system, paving the way for innovative therapeutic interventions and advancements in the field of immunology.

Product Title:FITC Anti-Human CD47 Antibody [CC2C6D4]
SKU:AGEL0251
Size:20 Tests, 100 Tests, 200 Tests
Clone No:CC2C6D4
Synonyms:Leukocyte surface antigen CD47;Cd47;Integrin-associated protein;IAP;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:FITC Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:FITC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q08722
Gene ID:961
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD47 also known as Rh-associated protein, gp42, integrin-associated protein (IAP), and neurophilin, is a 42-52 kD member of the immunoglobulin superfamily containing a five-pass transmembrane attachment. Two splice variants have been described in the cytoplasmic tail, the shorter form is expressed in bone-marrow-derived cells, endothelial cells, and fibroblasts while the longer form is expressed by neural tissues. CD47 expression is widely distributed in hematopoietic cells including thymocytes, T cells, B cells, monocytes, platelets, and erythrocytes as well as epithelial cells, endothelial cells, fibroblasts, and neural tissues. CD47 functions as an adhesion molecule and thrombospondin receptor and is non-covalently associated with β3 integrins CD51/CD61, CD41/CD61. Thrombospondin is a ligand for CD47; in the absence of CD47 mice show defects in host defense and β3 integrin-dependent ligand binding, migration, and cellular activation. CD47 is also part of the Rh complex on erythrocytes.
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