Description
Human CDK14 Recombinant Protein (N-His)
Human CDK14 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Tyr135-Phe419, with an N-terminal His tag. Predicted molecular weight: 34.7 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Cyclin-dependent kinase 14 (CDK14) is a ~53 kDa protein. Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. For research use only.
Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.
| Product Name: | Human CDK14 Recombinant Protein (N-His) |
| SKU: | GXRP00297 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | hPFTAIRE1, KIAA0834, PFTK1, CDK14, Cyclin-dependent kinase 14, Cell division protein kinase 14, Serine/threonine-protein kinase PFTAIRE-1 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Tyr135-Phe419 |
| Calculated MW: | 34.7 kDa |
| UniProt: | O94921 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
