Description
Human CDKN1A Recombinant Protein (N-His)
Human CDKN1A Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Pro164, with an N-terminal His tag. Predicted molecular weight: 20.28 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Cyclin-dependent kinase inhibitor 1 (p21/CDKN1A) is a ~18 kDa protein. Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest. For research use only.
Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1.
| Product Name: | Human CDKN1A Recombinant Protein (N-His) |
| SKU: | GXRP01535 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | CDKN1, MDA-6, Cyclin-dependent kinase inhibitor 1, CIP1, WAF1, CDKN1A, p21, PIC1, Melanoma differentiation-associated protein 6, MDA6, SDI1, CDK-interacting protein 1, CAP20 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Pro164 |
| Calculated MW: | 20.28 kDa |
| UniProt: | P38936 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
