Description
Human CHD8 Recombinant Protein (N-His)
Human CHD8 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ser637-Ser780, with an N-terminal His tag. Predicted molecular weight: 19.82 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. ATP-dependent chromatin remodeler CHD8 is a ~290 kDa protein. ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP. For research use only.
Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes.
| Product Name: | Human CHD8 Recombinant Protein (N-His) |
| SKU: | GXRP11058 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | ATP-dependent helicase CHD8, CHD-8, CHD8, Chromodomain-helicase-DNA-binding protein 8, EC:3.6.4.-, HELSNF1, Helicase with SNF2 domain 1, KIAA1564 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ser637-Ser780 |
| Calculated MW: | 19.82 kDa |
| UniProt: | Q9HCK8 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
