Description
Human CILP Recombinant Protein (N-GST)
Human CILP Recombinant Protein (N-GST) is a recombinant protein expressed in E. coli, spanning Ile603-Ala846, with an N-terminal GST tag. Predicted molecular weight: 54.43 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Cartilage intermediate layer protein 1 (CILP) is a ~132 kDa protein. Probably plays a role in cartilage scaffolding. For research use only.
May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.
| Product Name: | Human CILP Recombinant Protein (N-GST) |
| SKU: | GXRP00231 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | CILP-1, Cartilage intermediate-layer protein, Cartilage intermediate layer protein 1, CILP |
| Tag: | N-GST |
| Expression Host: | E. coli |
| Protein Length: | Ile603-Ala846 |
| Calculated MW: | 54.43 kDa |
| UniProt: | O75339 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
