Description
Human GSK3A Recombinant Protein (N-GST)
Human GSK3A Recombinant Protein (N-GST) is a recombinant protein expressed in E. coli, spanning Gln115-Leu409, with an N-terminal GST tag. Predicted molecular weight: 60.69 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Glycogen synthase kinase-3 alpha (GSK3A) is a ~50 kDa protein. Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. For research use only.
Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors.
| Product Name: | Human GSK3A Recombinant Protein (N-GST) |
| SKU: | GXRP01709 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | GSK-3 alpha, GSK3A, Glycogen synthase kinase-3 alpha, Serine/threonine-protein kinase GSK3A |
| Tag: | N-GST |
| Expression Host: | E. coli |
| Protein Length: | Gln115-Leu409 |
| Calculated MW: | 60.69 kDa |
| UniProt: | P49840 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
