Description
Human CNOT1 Recombinant Protein (N-His)
Human CNOT1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Gln1356-Asp1607, with an N-terminal His tag. Predicted molecular weight: 30.77 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. CCR4-NOT transcription complex subunit 1 (CNOT1) is a ~266 kDa protein. Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. For research use only.
Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C.
| Product Name: | Human CNOT1 Recombinant Protein (N-His) |
| SKU: | GXRP04105 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Negative regulator of transcription subunit 1 homolog, hNOT1, NOT1H, CNOT1, CDC39, NOT1, CCR4-associated factor 1, KIAA1007, CCR4-NOT transcription complex subunit 1 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Gln1356-Asp1607 |
| Calculated MW: | 30.77 kDa |
| UniProt: | A5YKK6 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
