Description
Human DIO1 Recombinant Protein (N-His)
Human DIO1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Gly89-Ser254, with an N-terminal His tag. Predicted molecular weight: 20.77 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Type I iodothyronine deiodinase (DIO1) is a ~28 kDa protein. Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination. For research use only.
Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3), 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (3,3'-T2) and 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via outer-ring deiodination (ORD). Catalyzes the deiodination of T4 to 3,3',5'-triiodothyronine (rT3) via inner-ring deiodination (IRD). Catalyzes the deiodination of T3 to 3,3'-T2, 3,5-diiodothyronine (3,5-T2) to 3- monoiodothyronine (3-T1) and 3,3'-T2 to 3-T1 via IRD. Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine and 3',5'-diiodothyronamine.
| Product Name: | Human DIO1 Recombinant Protein (N-His) |
| SKU: | GXRP06187 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Type I iodothyronine deiodinase, 1.21.99.4, 5DI, DIOI, Type 1 DI, Type-I 5'-deiodinase, DIO1, ITDI1, TXDI1 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Gly89-Ser254 |
| Calculated MW: | 20.77 kDa |
| UniProt: | P49895 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
