Description
Human DNAJB9 Recombinant Protein (N-His)
Human DNAJB9 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ser24-Gln223, with an N-terminal His tag. Predicted molecular weight: 25.28 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. DnaJ homolog subfamily B member 9 (DNAJB9) is a ~25 kDa protein. Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). For research use only.
J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins. In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1. Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production.
| Product Name: | Human DNAJB9 Recombinant Protein (N-His) |
| SKU: | GXRP04521 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Microvascular endothelial differentiation gene 1 protein, ER-resident protein ERdj4, Endoplasmic reticulum DNA J domain-containing protein 4, Mdg-1, MDG1, DnaJ homolog subfamily B member 9, ERdj4, DNAJB9 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ser24-Gln223 |
| Calculated MW: | 25.28 kDa |
| UniProt: | Q9UBS3 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
