Description
Human DNAJC2 Recombinant Protein (N-His)
Human DNAJC2 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Lys442-Lys621, with an N-terminal His tag. Predicted molecular weight: 22.53 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. DnaJ homolog subfamily C member 2 (DNAJC2) is a ~71 kDa protein. Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. For research use only.
When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.
| Product Name: | Human DNAJC2 Recombinant Protein (N-His) |
| SKU: | GXRP02760 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | ZRF1, DNAJC2, DnaJ homolog subfamily C member 2, MPP11, MPHOSPH11, M-phase phosphoprotein 11, Zuotin-related factor 1 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Lys442-Lys621 |
| Calculated MW: | 22.53 kDa |
| UniProt: | Q99543 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
