Description
Human DPP9 Recombinant Protein (N-His)
Human DPP9 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ser36-Ser202, with an N-terminal His tag. Predicted molecular weight: 21.4 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Dipeptidyl peptidase 9 (DPP9) is a ~98 kDa protein. Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. For research use only.
Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8. Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation. The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP9, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition.
| Product Name: | Human DPP9 Recombinant Protein (N-His) |
| SKU: | GXRP02513 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Dipeptidyl peptidase 9, Dipeptidyl peptidase IX, DPRP-2, DPLP9, Dipeptidyl peptidase IV-related protein 2, DPP IX, DPP9, Dipeptidyl peptidase-like protein 9, DP9, DPRP2 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ser36-Ser202 |
| Calculated MW: | 21.4 kDa |
| UniProt: | Q86TI2 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
