Description
Human EPHB4 Recombinant Protein (C-His)
Human EPHB4 Recombinant Protein (C-His) is a recombinant protein expressed in mammalian cells, spanning Leu16-Ala539, with a C-terminal His tag. Predicted molecular weight: 60.33 kDa. Purity: >95% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Ephrin type-B receptor 4 (EPHB4) is a ~108 kDa protein. Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. For research use only.
The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells.
| Product Name: | Human EPHB4 Recombinant Protein (C-His) |
| SKU: | GXRP06842 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Hepatoma transmembrane kinase, Tyrosine-protein kinase TYRO11, HTK, EPHB4, Ephrin type-B receptor 4, TYRO11, MYK1 |
| Tag: | C-His |
| Expression Host: | Mammalian cells |
| Protein Length: | Leu16-Ala539 |
| Calculated MW: | 60.33 kDa |
| UniProt: | P54760 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >95% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
