Description
Human FBXO3 Recombinant Protein (N-His)
Human FBXO3 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Val155-Phe471, with an N-terminal His tag. Predicted molecular weight: 38.74 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. F-box only protein 3 (FBXO3) is a ~54 kDa protein. Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, SCF(FBXO3), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. For research use only.
Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. The SCF(FBXO3) also acts as a regulator of inflammation by mediating ubiquitination and degradation of FBXL2 in response to lipopolysaccharide (LPS).
| Product Name: | Human FBXO3 Recombinant Protein (N-His) |
| SKU: | GXRP03235 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | FBX3, FBXO3, F-box only protein 3 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Val155-Phe471 |
| Calculated MW: | 38.74 kDa |
| UniProt: | Q9UK99 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
