Description
Human GRK6 Recombinant Protein (N-His)
Human GRK6 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Phe186-Phe448, with an N-terminal His tag. Predicted molecular weight: 32.3 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. G protein-coupled receptor kinase 6 (GRK6) is a ~65 kDa protein. Specifically phosphorylates the activated forms of G protein-coupled receptors. For research use only.
Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
| Product Name: | Human GRK6 Recombinant Protein (N-His) |
| SKU: | GXRP01611 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | GRK6, GPRK6, G protein-coupled receptor kinase 6, G protein-coupled receptor kinase GRK6 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Phe186-Phe448 |
| Calculated MW: | 32.3 kDa |
| UniProt: | P43250 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
