Description
Human HTR1A Recombinant Protein (N-His)
Human HTR1A Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ile218-Lys345, with an N-terminal His tag. Predicted molecular weight: 16.10 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. 5-hydroxytryptamine receptor 1A (HTR1A) is a ~46 kDa protein. G-protein coupled receptor for 5-hydroxytryptamine (serotonin). For research use only.
Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes.
| Product Name: | Human HTR1A Recombinant Protein (N-His) |
| SKU: | GXRP08172 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | G-21, 5-HT-1A, 5-HT1A, ADRB2RL1, ADRBRL1, Serotonin receptor 1A, 5-hydroxytryptamine receptor 1A, HTR1A |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ile218-Lys345 |
| Calculated MW: | 16.10 kDa |
| UniProt: | P08908 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
