Human IL11 Antibody (BI 765423) is a research-grade biosimilar antibody. It is a human IgG antibody. Reactivity: Human. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, flow cytometry, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.
Interleukin-11 (IL11) is a ~21 kDa protein. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'.
Product Name:
Human IL11 Antibody (BI 765423)
SKU:
GXBS02442
Size:
100 µg, 1 mg
Clone:
BI 765423
Target:
Adipogenesis inhibitory factor
Isotype:
IgG
Host Species:
Human
Reactivity:
Human
Applications:
ELISA, FACS, Functional assay, Research in vivo
Expression Host:
Mammalian cells
Synonyms:
BI-765423, BI765423, BI765423
Biological Activity:
In in vitro experiments using human fibroblasts, BI-765423 significantly inhibits fibroblast activation and reduced the progression of inflammation- and senescence-related pathological processes [1] [2]. In in vitro cellular senescence transformation experiments using human cells, BI-765423 effectively counteractes cellular senescence transformation, demonstrating potential anti-aging activity [1]. BI-765423 can extend the healthy lifespan of mammals by inhibiting IL-11 signaling, and also has inhibitory effects on pathological processes associated with idiopathic pulmonary fibrosis (IPF) [1] [2].
Purity:
>95% purity as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4
State of Matter:
Liquid
Regulatory Status:
For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
