Description
Human ING3 Recombinant Protein (N-His)
Human ING3 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Ser130, with an N-terminal His tag. Predicted molecular weight: 17.85 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Inhibitor of growth protein 3 (ING3) is a ~46 kDa protein. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. For research use only.
This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome.
| Product Name: | Human ING3 Recombinant Protein (N-His) |
| SKU: | GXRP05109 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | p47ING3, ING3, Inhibitor of growth protein 3 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Ser130 |
| Calculated MW: | 17.85 kDa |
| UniProt: | Q9NXR8 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
