Description
Human IZUMO1 Recombinant Protein (C-Strep)
Human IZUMO1 Recombinant Protein (C-Strep) is a recombinant protein expressed in mammalian cells, spanning Cys22-Pro254, with a C-terminal Strep tag. Predicted molecular weight: 31.46 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Izumo sperm-egg fusion protein 1 (IZUMO1) is a ~38 kDa protein. Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. For research use only.
The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Acts a ligand for the human-specific oolemma epitope FCRL3/MAIA during fertilization. FCRL3/MAIA replaces IZUMO1R/JUNO as IZUMO1 receptor after sperm-egg adhesion, which permits species-specific gamete fusion.
| Product Name: | Human IZUMO1 Recombinant Protein (C-Strep) |
| SKU: | GXRP06837 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Izumo sperm-egg fusion protein 1, IZUMO1, Oocyte binding/fusion factor, Sperm-specific protein izumo, OBF |
| Tag: | C-Strep |
| Expression Host: | Mammalian cells |
| Protein Length: | Cys22-Pro254 |
| Calculated MW: | 31.46 kDa |
| UniProt: | Q8IYV9 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
