Description
Human KDM3A Recombinant Protein (N-His)
Human KDM3A Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Thr941-Pro1321, with an N-terminal His tag. Predicted molecular weight: 46.45 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Lysine-specific demethylase 3A (KDM3A) is a ~147 kDa protein. Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. For research use only.
Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin.
| Product Name: | Human KDM3A Recombinant Protein (N-His) |
| SKU: | GXRP04136 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | KIAA0742, KDM3A, JMJD1, Jumonji domain-containing protein 1A, Lysine-specific demethylase 3A, [histone H3]-dimethyl-L-lysine(9) demethylase 3A, JmjC domain-containing histone demethylation protein 2A, TSGA, JHDM2A, JMJD1A |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Thr941-Pro1321 |
| Calculated MW: | 46.45 kDa |
| UniProt: | Q9Y4C1 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
