Description
Human MAPK12 Recombinant Protein (N-His)
Human MAPK12 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Tyr27-Phe311, with an N-terminal His tag. Predicted molecular weight: 34.68 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Mitogen-activated protein kinase 12 (MAPK12) is a ~41 kDa protein. Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. For research use only.
MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation.
| Product Name: | Human MAPK12 Recombinant Protein (N-His) |
| SKU: | GXRP01790 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Mitogen-activated protein kinase 12, ERK6, MAPK12, Extracellular signal-regulated kinase 6, ERK-6, MAP kinase p38 gamma, SAPK3, MAPK 12, Stress-activated protein kinase 3, MAP kinase 12, Mitogen-activated protein kinase p38 gamma |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Tyr27-Phe311 |
| Calculated MW: | 34.68 kDa |
| UniProt: | P53778 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
