Description
Human MARCHF8 Recombinant Protein (N-His)
Human MARCHF8 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ser13-Lys137, with an N-terminal His tag. Predicted molecular weight: 16.22 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. E3 ubiquitin-protein ligase MARCHF8 is a ~32 kDa protein. E3 ubiquitin-protein ligase that plays several important roles in innate immunity and adaptive immunity. For research use only.
Mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. Possesses a very broad antiviral activity by specifically inactivating different viral fusion proteins. Targets and ubiquitinates cytoplasmic lysine residues of viral envelope glycoproteins with single transmembrane domains leading to their lysosomal degradation. Therefore, shows broad-spectrum inhibition against many viruses including retroviruses, rhabdoviruses, arenaviruses, sarbecoviruses or influenzaviruses.
| Product Name: | Human MARCHF8 Recombinant Protein (N-His) |
| SKU: | GXRP04302 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Cellular modulator of immune recognition, E3 ubiquitin-protein ligase MARCHF8, MARCH-VIII, MIR, RING finger protein 178, MARCHF8, Membrane-associated RING-CH protein VIII, c-MIR, MARCH8, Membrane-associated RING finger protein 8, RNF178, RING-type E3 ubiquitin transferase MARCHF8 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ser13-Lys137 |
| Calculated MW: | 16.22 kDa |
| UniProt: | Q5T0T0 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
