Description
Human MAVS Recombinant Protein (N-His)
Human MAVS Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Pro2-Pro97, with an N-terminal His tag. Predicted molecular weight: 13.48 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Mitochondrial antiviral-signaling protein is a ~56 kDa protein. Adapter required for innate immune defense against viruses. For research use only.
Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3.
| Product Name: | Human MAVS Recombinant Protein (N-His) |
| SKU: | GXRP12285 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | CARD adapter inducing interferon beta, Cardif, IPS-1, IPS1, Interferon beta promoter stimulator protein 1, KIAA1271, MAVS, Mitochondrial antiviral-signaling protein, Putative NF-kappa-B-activating protein 031N, VISA, Virus-induced-signaling adapter |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Pro2-Pro97 |
| Calculated MW: | 13.48 kDa |
| UniProt: | Q7Z434 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
