Description
Human NOTCH1 Recombinant Protein (N-His)
Human NOTCH1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Lys1759-Ala2127, with an N-terminal His tag. Predicted molecular weight: 43.10 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Neurogenic locus notch homolog protein 1 is a ~272 kDa protein. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. For research use only.
Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus.
| Product Name: | Human NOTCH1 Recombinant Protein (N-His) |
| SKU: | GXRP12472 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | NEXT, NICD, NOTCH1, Neurogenic locus notch homolog protein 1, Notch 1, Notch 1 extracellular truncation, Notch 1 intracellular domain, TAN1, Translocation-associated notch protein TAN-1, hN1 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Lys1759-Ala2127 |
| Calculated MW: | 43.10 kDa |
| UniProt: | P46531 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
