Description
Human NOTCH2 Recombinant Protein (N-His)
Human NOTCH2 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ala2251-Asn2466, with an N-terminal His tag. Predicted molecular weight: 25.18 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Neurogenic locus notch homolog protein 2 (NOTCH2) is a ~265 kDa protein. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. For research use only.
Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation.
| Product Name: | Human NOTCH2 Recombinant Protein (N-His) |
| SKU: | GXRP02048 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | N2ICD, N2ECD, NOTCH2, hN2, Neurogenic locus notch homolog protein 2, Notch 2 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ala2251-Asn2466 |
| Calculated MW: | 25.18 kDa |
| UniProt: | Q04721 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
