Description
Human OAS3 Recombinant Protein (N-His)
Human OAS3 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ala745-Val1087, with an N-terminal His tag. Predicted molecular weight: 40.84 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. 2'-5'-oligoadenylate synthase 3 (OAS3) is a ~121 kDa protein. Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. For research use only.
In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.
| Product Name: | Human OAS3 Recombinant Protein (N-His) |
| SKU: | GXRP07968 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | 2-5A synthase 3, p100 OAS, p100OAS, (2-5')oligo(A) synthase 3, 2'-5'-oligoadenylate synthase 3, OAS3 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ala745-Val1087 |
| Calculated MW: | 40.84 kDa |
| UniProt: | Q9Y6K5 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
