Description
Human PHEX Recombinant Protein (N-His)
Human PHEX Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ser41-Arg391, with an N-terminal His tag. Predicted molecular weight: 43.08 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Phosphate-regulating neutral endopeptidase PHEX is a ~86 kDa protein. Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity. For research use only.
Cleaves ASARM peptides between Ser and Glu or Asp residues. Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide. Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides. Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation.
| Product Name: | Human PHEX Recombinant Protein (N-His) |
| SKU: | GXRP01955 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | X-linked hypophosphatemia protein, Vitamin D-resistant hypophosphatemic rickets protein, Metalloendopeptidase homolog PEX, HYP, PHEX, PEX, Phosphate-regulating neutral endopeptidase PHEX |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ser41-Arg391 |
| Calculated MW: | 43.08 kDa |
| UniProt: | P78562 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
