Description
Human POU4F2 Recombinant Protein (N-His)
Human POU4F2 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ser243-Ile409, with an N-terminal His tag. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. POU domain, class 4, transcription factor 2 is a ~43 kDa protein. Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells. For research use only.
Functions either as activator or repressor modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner. Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to an octamer site to form a ternary complex with ISL1; cooperates positively with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being involved in RGC fate commitment in the developing retina and RGC axon formation and pathfinding.
| Product Name: | Human POU4F2 Recombinant Protein (N-His) |
| SKU: | GXRP13284 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | BRN3B, Brain-3B, Brain-specific homeobox/POU domain protein 3B, Brn-3B, POU domain, class 4, transcription factor 2, POU4F2 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ser243-Ile409 |
| UniProt: | Q12837 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
