Description
Human ROCK2 Recombinant Protein (N-His)
Human ROCK2 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Glu907-Gly1140, with an N-terminal His tag. Predicted molecular weight: 29.21 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Rho-associated protein kinase 2 (ROCK2) is a ~160 kDa protein. Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. For research use only.
Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation.
| Product Name: | Human ROCK2 Recombinant Protein (N-His) |
| SKU: | GXRP00222 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | ROCK2, KIAA0619, Rho-associated, coiled-coil-containing protein kinase 2, p164 ROCK-2, ROCK-II, Rho kinase 2, Rho-associated, coiled-coil-containing protein kinase II, Rho-associated protein kinase 2 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Glu907-Gly1140 |
| Calculated MW: | 29.21 kDa |
| UniProt: | O75116 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
