Description
Human ROS1 Recombinant Protein (N-His)
Human ROS1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Leu1945-Phe2222, with an N-terminal His tag. Predicted molecular weight: 34.05 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Proto-oncogene tyrosine-protein kinase ROS (ROS1) is a ~263 kDa protein. Receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. For research use only.
NELL2 is an endogenous ligand for ROS1. Upon endogenous stimulation by NELL2, ROS1 activates the intracellular signaling pathway and triggers epididymal epithelial differentiation and subsequent sperm maturation. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway.
| Product Name: | Human ROS1 Recombinant Protein (N-His) |
| SKU: | GXRP00752 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Proto-oncogene tyrosine-protein kinase ROS, Receptor tyrosine kinase c-ros oncogene 1, c-Ros receptor tyrosine kinase, Proto-oncogene c-Ros-1, Proto-oncogene c-Ros, ROS, ROS1, MCF3 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Leu1945-Phe2222 |
| Calculated MW: | 34.05 kDa |
| UniProt: | P08922 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
